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| http://dx.doi.org/10.1007/s00125-024-06187-4 | DOI Listing |
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Understanding inter-individual variability of experimental pain habituation and conditioned pain modulation in healthy individuals.
Sci Rep
September 2024
Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008, Zurich, Switzerland.
Article Synopsis
- - The study explores the relationship between pain habituation (how pain response decreases over time) and conditioned pain modulation (CPM), which is a measure of the body’s ability to manage pain, in 45 healthy participants.
- - Pain habituation was evaluated using subjective pain ratings and objective measures (CHEP and SSR) during heat stimuli, revealing significant variability in participants’ responses, particularly in subjective ratings.
- - It was found that while subjective pain habituation correlated with cold-induced CPM effects, this correlation did not hold for other CPM measures, suggesting that subjective and objective pain responses may reflect different aspects of how our body modulates pain.
Inhibition of RHOA activity preserves the survival and hemostasis function of long-term cold-stored platelets.
Blood
October 2024
Hoxworth Blood Center, University of Cincinnati College of Medicine, Cincinnati, OH.
Patients with thrombocytopenia require platelet transfusion to prevent and stop hemorrhage. Cold storage of platelets results in complex molecular lesions, including changes in membrane microdomains that are recognized by host macrophages and hepatocyte counter-receptors, resulting in phagocytosis and clearance upon transfusion. For this reason, platelets are stored at room temperature, a method that confers increased risk of bacterial contamination.
View Article and Find Full Text PDFSMRT sequencing of a full-length transcriptome reveals cold induced alternative splicing in Vitis amurensis root.
Plant Physiol Biochem
August 2024
State Key Laboratory of Plant Diversity and Specialty Crops, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China. Electronic address:
Alternative splicing enhances diversity at the transcriptional and protein levels that widely involved in plant response to biotic and abiotic stresses. V. amurensis is an extremely cold-tolerant wild grape variety, however, studies on alternative splicing (AS) in amur grape at low temperatures are currently poorly understood.
View Article and Find Full Text PDFCorrection: Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia.
Diabetologia
August 2024
Division of Systems Medicine, School of Medicine, University of Dundee, Dundee, UK.
Oxaliplatin causes increased offset analgesia during chemotherapy - a feasibility study.
Scand J Pain
October 2023
Center for Neuroplasticity and Pain (CNAP), Aalborg University, Aalborg, Denmark.
Objectives: Offset analgesia (OA) is the phenomenon where the perceived pain intensity to heat stimulation disproportionally decreases after a slight decrease in stimulation temperature. The neural mechanisms of OA are not fully understood, but it appears that both peripheral and central temporal filtering properties are involved. Chemotherapy with oxaliplatin often causes acute peripheral sensory neuropathy, and manifests primarily as a cold induced allodynia.
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