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Attempts to Create Transgenic Mice Carrying the Q3924E Mutation in RyR2 Ca Binding Site.
Cells
December 2024
Cardiac Signaling Center, University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, USA.
Over 200 point mutations in the ryanodine receptor (RyR2) of the cardiac sarcoplasmic reticulum (SR) are known to be associated with cardiac arrhythmia. We have already reported on the calcium signaling phenotype of a point mutation in RyR2 Ca binding site Q3925E expressed in human stem-cell-derived cardiomyocytes (hiPSC-CMs) that was found to be lethal in a 9-year-old girl. CRISPR/Cas9-gene-edited mutant cardiomyocytes carrying the RyR2-Q3925E mutation exhibited a loss of calcium-induced calcium release (CICR) and caffeine-triggered calcium release but continued to beat arrhythmically without generating significant SR Ca release, consistent with a remodeling of the calcium signaling pathway.
View Article and Find Full Text PDFCoffee consumption and adverse cardiovascular events in patients with atrial fibrillation.
BMC Med
December 2024
Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Background: There is some evidence of reduced major cardiovascular event (MACE) rates associated with moderate coffee consumption in the general population. However, there is concern about the potential risks of coffee consumption in patients with atrial fibrillation (AF). Therefore, we aimed to investigate the association between coffee consumption and MACE in AF patients.
View Article and Find Full Text PDFG-protein-coupled receptor 41 in cardiomyocytes: Effect of butyrate on intracellular Ca and sarcomere shortening.
FASEB J
December 2024
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
G-protein-coupled receptor 41 (GPR41) is a Gα-coupled receptor activated by short-chain fatty acids (SCFAs). Here, we tested that GPR41 is also expressed in cardiomyocytes and exerts a direct negative inotropic effect when activated by SCFA butyrate. Primary cardiomyocytes were isolated from wild-type (WT) and GPR41 knockout (GPR41) adult mice and intracellular Ca concentration and cell shortening were measured using the IonOptix system.
View Article and Find Full Text PDFβ-Adrenergic receptor signalling pathway mediated antiarrhythmic activity of s-limonene in the rat heart.
Clin Exp Pharmacol Physiol
October 2024
Department of Physiology, Federal University of Sergipe, Sao Cristovao, Brazil.
S-Limonene (s-Lim) is a monocyclic monoterpene found in a variety of plants and has been shown to present antioxidant and cardioprotective activity in experimental models of myocardial infarction. The aim of this study was to evaluate the potential mechanism by which s-Lim exerts its antiarrhythmic effect, focusing on the blockade of β-adrenoceptor (β-AR) and its effects on various in vivo and in vitro parameters, including electrocardiogram (ECG) measurements, left ventricular developed pressure (LVDP), the β-adrenergic pathway, sarcomeric shortening and L-type calcium current (I). In isolated hearts, 10 μM of s-Lim did not alter the ECG profile or LVPD.
View Article and Find Full Text PDFAcute Cardiovascular Effects of Simultaneous Energy Drink and Alcohol Consumption in Young Adults: A Review of Case Reports.
Pediatr Rep
July 2024
Department of Pediatric Cardiology and Intensive Care, University Hospital of Munich, Ludwig-Maximilians-University, 81377 Munich, Germany.
(1) Background: The aim of this review was to identify and summarize adverse cardiovascular health events associated with the simultaneous consumption of energy drinks (ED) and alcohol. Potential prevention strategies and the implementation of research toward the underlying mechanisms for these pathologies were highlighted to emphasize the need for further investigation and to encourage more attention to this field. (2) Methods: The PubMed database was searched for case reports linked with adverse cardiovascular events after simultaneous ED and alcohol consumption.
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