Background: As artificial intelligence within digital processes continues to advance and replace conventional manual workflows, it is crucial that digital data are consistent with analog data. The aim was to evaluate the validity and time efficiency of digital cast analysis on digital models in comparison with the manual, gold standard, cast analysis on plaster models.
Methods: Cast analysis was performed on 30 patients in three various methods: manually measured variables on plaster models (MP), manually measured variables on digital three-dimensional models (MD), and automatically measured variables on digital three-dimensional models (AD) on digital models. Digital cast analysis was performed in CS Model+. Analyses included metrical and categorical variables and the required work time. Measurements in MD and AD were validated to MP. Validity of the metrical variables was analyzed with Bland-Altman, Dahlberg's formula, and paired sample t test. Categorical variables were validated by Cohen's Kappa. Work time was analyzed with Wilcoxon signed-rank test.
Results: Metrical variables had measurement errors ranging 0.4 to 1.4 mm between MP-MD, and 0.6 to 3.2 mm between MP-AD. Observations of categorical variables had a moderate to strong (0.65 to 0.9) level of agreement between MP-MD, and a weak to moderate (0.4 to 0.68) level of agreement between MP-AD. Data for dental stage, vertical, and transversal relation was not provided in AD. Cast analysis was performed quicker digitally, P ≤ 0.05.
Conclusions: Digital cast analysis is consistent with manual cast analysis for metrical variables. Analyses of categorical variables show a weak level of agreement with automatic digital analysis, such as space conditions and midline assessments. Digital cast analysis optimizes time compared with manual cast analysis, with automatic analysis being the fastest.
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http://dx.doi.org/10.1016/j.ejwf.2024.04.002 | DOI Listing |
Mol Biol Cell
January 2025
Laboratory of Cancer Pathology, Centre for Advanced Studies and Technology (CAST), University "G. D'Annunzio", Chieti, Italy.
The transmembrane glycoproteins Trop-1/EpCAM and Trop-2 independently trigger Ca and kinase signals for cell growth and tumor progression. Our findings indicated that Trop-1 and Trop-2 tightly colocalize at macroscopic, ruffle-like protrusions (RLP), that elevate from the cell perimeter, and locally recur over hundreds of seconds. These previously unrecognized elevated membrane regions ≥20 µm-long, up to 1.
View Article and Find Full Text PDFFASEB J
January 2025
Department of Hematology, Nephrology, and Rheumatology, Graduate School of Medicine, Akita University, Akita, Japan.
Various tubular diseases in patients with multiple myeloma (MM) are caused by monoclonal immunoglobulin light chains (LCs). However, the physicochemical characteristics of the disease-causing LCs contributing to the onset of MM-associated tubular diseases remain unclear. We herein report a rare case of MM-associated combined tubulopathies: non-crystalline light chain proximal tubulopathy (LCPT) and crystalline light chain cast nephropathy (LCCN).
View Article and Find Full Text PDFGigascience
January 2025
Centre for Evolutionary & Organismal Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Background: A thorough analysis of genome evolution is fundamental for biodiversity understanding. The iconic monotremes (platypus and echidna) feature extraordinary biology. However, they also exhibit rearrangements in several chromosomes, especially in the sex chromosome chain.
View Article and Find Full Text PDFOrthod Craniofac Res
January 2025
Department of Orthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Background: Different protocols exist regarding wear time of invisible aligners. There is no study that compared the effect of different protocols. The aim of this study was to assess the effect of Invisalign aligners in four first-premolar extraction treatments in adolescents using three aligner wear protocols, every 7, 10 and 14 days.
View Article and Find Full Text PDFEmerg Radiol
January 2025
Department of Orthopaedics, Institute of Clinical Sciences, Lund University, Lund, Sweden.
Purpose: To evaluate the rate of missed scaphoid fractures on follow-up computed tomography (CT) for suspected occult scaphoid fracture after normal radiography with residual radial-sided wrist pain.
Methods: In a retrospective analysis, wrist CT during a five-year period was analyzed. The CT examinations and radiological reports were re-evaluated.
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