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The frequency of HLA-DQ7 in patients at risk of coeliac disease: A haplotype to be reckoned with for screening?
Hum Immunol
November 2024
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Immunology Laboratory, Department of Clinical Chemistry, Amsterdam Infection and Immunity Institute, Amsterdam, The Netherlands.
Article Synopsis
- * This study analyzed 3,983 patients at risk for CD over four years, focusing on those who were HLA-DQ7 positive but negative for HLA-DQ2/DQ8.
- * Only one patient was diagnosed with CD among the 325 suitable for analysis, suggesting that HLA-DQ7 typing may not be necessary for routine screening in high-risk populations like those in the Netherlands, although it could be useful in cases with a strong suspicion of CD.
HLA-DQ7 haplotype among individuals with suspected celiac disease.
Dig Liver Dis
August 2024
Celiac Center Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215 USA; Celiac Research Program, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 USA. Electronic address:
What does not look like celiac disease and instead it is.
Gastroenterol Hepatol Bed Bench
January 2023
Department of Medicine and Surgery, Section of Anatomic Pathology and Histology, Medical School, University of Perugia, Perugia, Italy.
The celiac disease (CD) diagnosis sometimes is challenging and diagnostic process cannot always follow a simple algorithm but it requires a close collaboration between histo-pathologists, clinicians, laboratory and genetic experts. The genetic predisposition for CD is related to HLA-DQ2 and/or DQ8 but other HLA haplotypes and non-HLA genes may be involved in genetic predisposition. In particular DQ7 may represent an additive and independent CD risk associated haplotype.
View Article and Find Full Text PDFHLA Loci and Recurrence of Focal Segmental Glomerulosclerosis in Pediatric Kidney Transplantation.
Transplant Direct
October 2021
Department of Surgery, Duke University, Durham, NC.
Unlabelled: Recurrent focal segmental glomerulosclerosis (FSGS) after kidney transplantation accounts for the majority of allograft failures in children with primary FSGS. Although current research focuses on FSGS pathophysiology, a common etiology and mechanisms of disease recurrence remain elusive.
Methods: We performed a retrospective review of the Scientific Registry of Transplant Recipients to determine the association of specific HLA recurrence of FSGS.
HLA class II immunopeptidomics reveals that co-inherited HLA-allotypes within an extended haplotype can improve proteome coverage for immunosurveillance.
Proteomics
September 2021
Department of Biochemistry and Molecular Biology and Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Human leucocyte antigen (HLA) class II molecules in humans are encoded by three different loci, HLA-DR, -DQ, and -DP. These molecules share approximately 70% sequence similarity and all present peptide ligands to circulating T cells. While the peptide repertoires of numerous HLA-DR, -DQ, and -DP allotypes have been examined, there have been few reports on the combined repertoire of these co-inherited molecules expressed in a single cell as an extended HLA haplotype.
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