Cancer, as a public health issue, is the leading cause of death worldwide. Tetrahydroisoquinoline derivatives have effective biological activities and can be used as potential therapeutic agents for antitumor drugs. In this work, we designed and synthesized a series of novel tetrahydroisoquinoline compounds and evaluated their antitumor activity in vitro on several representative human cancer cell lines. The results showed that the vast majority of compounds showed good inhibitory activities against the cancer cell lines of HCT116, MDA-MB-231, HepG2, and A375.
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Article Synopsis
- The study focused on synthesizing new compounds, specifically 5,6,7,8-tetrahydroisoquinolines and 6,7,8,9-tetrahydrothieno[2,3-c]isoquinolines, and confirmed their structures using various spectroscopic techniques.
- Anticancer activities of these new compounds were tested against eight tumor cell lines, revealing that compound 3 was most effective against the HEPG2 cell line and compound 9c against the HCT116 cell line.
- Further analysis showed that compound 3 induced significant apoptosis and cell cycle arrest in HEPG2 cells, while molecular docking studies indicated that compounds 3
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