AI Article Synopsis
- - Multiple sclerosis (MS) is an autoimmune disease where the immune system attacks the protective myelin sheath in the nervous system, with dendritic cells (DCs) playing a key role in its progression.
- - Quercetin (QU) shows promise for treating autoimmune diseases, but its exact mechanism in addressing experimental autoimmune encephalomyelitis (EAE), a model for MS, wasn't well understood.
- - This study reveals that QU has anti-inflammatory and neuroprotective effects by inhibiting DC activation and modifying Th17 cell differentiation, potentially targeting the STAT4 pathway in DCs.
Article Abstract
Multiple sclerosis (MS) is a class of autoimmune diseases mainly caused by the immune system attacking the myelin sheath of the axons in the nervous system. Although the pathogenesis of MS is complex, studies have shown that dendritic cells (DCs) play a vital role in the pathogenesis of MS. Quercetin (QU) has a unique advantage in clinical application, especially for treating autoimmune diseases. However, the mechanism of QU in the treatment of experimental autoimmune encephalomyelitis (EAE) remains unclear. In this study, we explore the potential role of QU in EAE. Finally, we find that QU has anti-inflammatory activities and neural protective effects in EAE. The experimental results suggest that the cellular basis for QU's function is to inhibit the activation of DCs while modulating the Th17 cell differentiation in the co-culture system. Further, QU may target STAT4 to inhibit its activation in DCs. This work will be of great significance for the future development and utilization of QU.
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| http://dx.doi.org/10.1016/j.taap.2024.116980 | DOI Listing |
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