AI Article Synopsis
- Aberrant levels of HClO (hypochlorous acid) are significant health risks and are common reactive oxygen species in living organisms, making their detection important. //! -
- Researchers developed a near-infrared fluorescent probe called DCMP1, which features an oxime group for detecting HClO and has a quick response time, high selectivity, and emits light at 660 nm. //! -
- DCMP1 successfully detects HClO in living cells, zebrafish, and rheumatoid arthritis mouse models, suggesting it could be a valuable tool for studying HClO's role in health and disease.
Article Abstract
It is crucial to identify aberrant HClO levels in living things since they pose a major health risk and are a frequent reactive oxygen species (ROS) in living organisms. In order to detect HClO in various biological systems, we created and synthesized a near-infrared fluorescent probe with an oxime group (-C = N-OH) as a recognition unit. The probe DCMP1 has the advantages of fast response (10 min), near-infrared emission (660 nm), large Stokes shift (170 nm) and high selectivity. This probe DCMP1 not only detects endogenous HClO in living cells, but also enables further fluorescence detection of HClO in living zebrafish. More importantly, it can also be used for fluorescence imaging of HClO in an rheumatoid arthritis mouse model. This fluorescent probe DCMP1 is anticipated to be an effective tool for researching HClO.
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| http://dx.doi.org/10.1016/j.saa.2024.124547 | DOI Listing |
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