Liver disease occurring as a manifestation of secondary syphilis is unusual, and this association is not readily recognized or considered in the differential diagnosis of obscure hepatic disease, thereby causing delay in treatment. We describe a case of liver involvement in secondary syphilis with computed-tomography and ultrasound findings. This entity should be considered in patients with hepatomegaly coexisting with the clinical stigmata of secondary syphilis, as treatment with penicillin results in rapid improvement in both the clinical and biochemical findings.
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