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| http://dx.doi.org/10.1111/jcmm.18479 | DOI Listing |
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Novel role of zinc-finger protein 518 in heterochromatin formation on α-satellite DNA.
Nucleic Acids Res
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Laboratory of Chromosome Engineering, Department of Frontier Research and Development, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu 292-0818, Japan.
Aneuploidy is caused by chromosomal missegregation and is frequently observed in cancers and hematological diseases. Therefore, it is important to understand the molecular mechanisms underlying chromosomal segregation. The centromere's intricate structure is crucial for proper chromosome segregation, with heterochromatin at the pericentromeric α-satellites playing a key role.
View Article and Find Full Text PDFComprehensive gene set enrichment and variation analyses identify as a potential prognostic biomarker for glioblastoma immunorelevance.
Comput Struct Biotechnol J
December 2024
Key Laboratory of Pathobiology, Ministry of Education, Department of Biomedical Science, College of Basic Medical Sciences, Jilin University, Changchun, China.
Glioblastoma (GBM) is the most common intracranial malignancy. encodes a histone H3 lysine 9 methyltransferase that acts as an oncogene in several cancers; however, its role in GBM remains unknown. We obtained GBM transcriptome and clinical data from The Cancer Genome Atlas (TCGA) database on the UCSC Xena platform to perform differential and enrichment analyses of genes in the high- and low-expression groups to construct a prognostic risk model.
View Article and Find Full Text PDFRedox-sensitive epigenetic activation of SUV39H1 contributes to liver ischemia-reperfusion injury.
Redox Biol
December 2024
Department of Pathology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China. Electronic address:
Liver ischemia-reperfusion (I/R) injury is a clinically relevant pathophysiological process that determines the effectiveness of life-saving liver transplantation, to which aberrant ROS accumulation plays a key role. In the present study we investigated the role of SUV39H1, a lysine methyltransferases, in this process focusing on regulatory mechanism and translational potential. We report that SUV39H1 expression was up-regulated in the liver tissues of mice subjected to ischemia-reperfusion and in hepatocytes exposed to hypoxia-reoxygenation (H/R) in a redox-sensitive manner.
View Article and Find Full Text PDFCardiac-specific Suv39h1 knockout ameliorates high-fat diet induced diabetic cardiomyopathy via regulating Hmox1 transcription.
Life Sci
January 2025
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, 1 Wenyuan Rd, Nanjing 210023, China. Electronic address:
Aim: Diabetic Cardiomyopathy (DCM), a common complication of Type 2 Diabetic Mellitus (T2DM), has been emerging as one of the leading causes of mortality in T2DM patients. During the past decade, although, clinical studies concerning DCM are increasing at an exponential rate, mechanisms underlying this disease still can't be clearly defined. Here, we aim to recognize the function of Suv39h1 in DCM and to explore underlying mechanisms during this disease, providing new insights into DCM and novel guide for clinical therapy development.
View Article and Find Full Text PDFClr4 ubiquitination and non-coding RNA mediate transcriptional silencing of heterochromatin via Swi6 phase separation.
Nat Commun
October 2024
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, USA.
Article Synopsis
- Transcriptional silencing by RNA interference (RNAi) involves a complex process that requires the presence of transcription, specifically in Schizosaccharomyces pombe where the Cryptic Loci Regulator complex (CLRC) plays a crucial role.
- CLRC, functioning as a cullin-ring E3 ligase, interacts with the E2 enzyme Ubc4, which modifies the histone methyltransferase Clr4, facilitating the shift from co-transcriptional to transcriptional gene silencing through different forms of histone methylation.
- The study highlights the importance of phase separation and the role of non-coding RNA in regulating this process, impacting other transcriptional
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