AI Article Synopsis
- Dissecting cellulitis of the scalp (DCS) negatively affects patients' physical well-being and body image, and conventional treatments often fail, prompting the exploration of alternative therapies like 5-aminolevulinic acid photodynamic therapy (ALA-PDT).
- The study involved 12 male patients treated with ALA-PDT, with results assessed through symptom scores and photographic comparisons taken before and after the treatment, focusing on pain relief and recurrence rates.
- Results indicated that 75% of patients experienced significant reductions in symptoms, with notable improvements in pain relief, subcutaneous sinus tract symptoms, and alopecia, along with a decrease in inflammatory cells in the lesions.
Article Abstract
Background: Dissecting cellulitis of the scalp (DCS) has a significant impact on the physical well-being and body image of the patient. Since DCS often responds poorly to conventional treatments, there is a need to identify alternative treatment strategies. This study aimed to explore the effectiveness of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating DCS.
Methods: Twelve male patients with DCS treated solely with ALA-PDT between June 2022 and June 2023 at our institution were enrolled in this study. Two patients underwent a biopsy before and after treatment for comparison. The efficacy of the treatments was assessed 10 days after treatment by evaluating the symptom scores recorded on medical records and by assessing the photographs acquired before and after treatment. In addition, the impact of the treatment on pain relief and median recurrence rate were also extracted.
Results: Out of the 12 enrolled patients, the majority of the patients (75%) had a significant reduction in the nodules or abscesses. The pain relief was significant in 3 patients (25%), and moderate in 7 patients (58.3%). For the subcutaneous sinus tract symptoms, 3 patients (27.3%) showed moderate improvement, and 7 (63.6%) had a mild improvement. Six patients (75%) had mild improvement in their alopecia. The pathology results showed a decrease in the number of lymphocytes, macrophages, and neutrophils within the skin lesions following the administration of ALA-PDT.
Conclusion: ALA-PDT can effectively reduce the DCS symptoms and the number of lymphocytes, macrophages, and neutrophils within the skin lesions.
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| http://dx.doi.org/10.1016/j.pdpdt.2024.104227 | DOI Listing |
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