AI Article Synopsis
- Neuropsychological studies indicate that anxiety and depression symptoms are common in patients with lifestyle disorders, but their effects on movement are not well understood.
- This study explores how high fat diet, chronodisruption, and their combination impact locomotor function by examining changes in cerebellar gene expression and signaling pathways.
- Results show significant deficits in locomotor ability across all experimental groups, along with notable inflammation and damage to Purkinje cells in the cerebellum, highlighting the relationship between cerebellar function, movement, and certain genetic pathways.
Article Abstract
Neuropsychological studies report anxiety and depression like symptoms in patients suffering from lifestyle disorder but its impact on locomotor function lacks clarity. Our study investigates locomotor deficits resulting due to perturbations in cerebellum of high fat diet (HFD), chronodisruption (CD) or a combination (HCD) model of lifestyle disorder. Significant downregulation in levels of cerebellar clock genes (Bmal-1, Clock, Per 1 and Per 2) and Bdnf-Trkb pathway genes (Bdnf, TrkB and Syn1 levels) were recorded. Further, locomotor deficits were observed in all the three experimental groups as evidenced by actimeter test, pole test and wire hanging test. Nuclear pyknosis of Purkinje cells, their derangement and inflammation were the hallmark of cerebellar tissue of all the three experimental groups. Taken together, this study generates important links between cerebellar clock oscillations, locomotor function and Bdnf-TrkB signaling.
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| http://dx.doi.org/10.1016/j.neulet.2024.137843 | DOI Listing |
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