AI Article Synopsis
- Chorioamnionitis (CAM) is an infection and inflammation of the membranes surrounding the fetus, but effective diagnostic biomarkers are currently lacking.!* -
- The study examined the role of the RNA editing enzyme ADAR1 in diagnosing CAM by analyzing specimens from patients with premature rupture of membranes and diagnosed CAM using RT-PCR.!* -
- Results showed that ADAR1 levels were significantly higher in CAM patients, suggesting it could serve as a reliable diagnostic biomarker compared to existing inflammatory and clinical markers.!*
Article Abstract
Introduction: Chorioamnionitis (CAM) involves infection and inflammation of the chorion and amniotic membrane, but there are still no effective diagnostic biomarkers for CAM.
Methods: We investigated the correlation between RNA editing enzyme Adenosine deaminase family acting on RNA 1 (ADAR1) and CAM in chorion and amniotic membrane specimens derived from premature rupture of the membrane (PROM), CAM (pathologically diagnosed), and clinical CAM (clinically diagnosed) patients using reverse transcription polymerase chain reaction (RT-PCR).
Results: ADAR1 was upregulated in the chorion and amniotic membrane specimens of CAM and clinical CAM patients (p < 0.001 and p = 0.005). ADAR1 had a significantly higher area under the curve (AUC) (0.735 and 0.828) than markers of inflammation characteristics in diagnosing CAM and clinical CAM patients. ADAR1 also had significantly higher AUC (0.701 and 0.837) than clinical characteristics for CAM and clinical CAM patients.
Discussion: ADAR1 can be a useful diagnostic biomarker in CAM patients.
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| http://dx.doi.org/10.1016/j.placenta.2024.05.133 | DOI Listing |
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