AI Article Synopsis
- Atrazine (ATR) is a common herbicide that can harm kidneys in humans and animals by accumulating in water and soil.
- Lycopene (LYC), a carotenoid known for its antioxidant and anti-inflammatory properties, was investigated for its protective effects against kidney damage caused by ATR.
- The study found that LYC effectively reduces ATR-induced kidney damage by inhibiting the cGAS-STING signaling pathway, highlighting its potential as a therapeutic option for renal diseases.
Article Abstract
Atrazine (ATR) is a widely used herbicide worldwide that can cause kidney damage in humans and animals by accumulation in water and soil. Lycopene (LYC), a carotenoid with numerous biological activities, plays an important role in kidney protection due to its potent antioxidant and anti-inflammatory effects. The current study sought to investigate the role of interactions between mtDNA and the cGAS-STING signaling pathway in LYC mitigating PANoptosis and inflammation in kidneys induced by ATR exposure. In our research, 350 mice were orally administered LYC (5 mg/kg BW/day) and ATR (50 or 200 mg/kg BW/day) for 21 days. Our results reveal that ATR exposure induces a decrease in mtDNA stability, resulting in the release of mtDNA into the cytoplasm through the mPTP pore and the BAX pore and the mobilization of the cGAS-STING pathway, thereby inducing renal PANoptosis and inflammation. LYC can inhibit the above changes caused by ATR. In conclusion, LYC inhibited ATR exposure-induced histopathological changes, renal PANoptosis, and inflammation by inhibiting the cGAS-STING pathway. Our results demonstrate the positive role of LYC in ATR-induced renal injury and provide a new therapeutic target for treating renal diseases in the clinic.
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| http://dx.doi.org/10.1021/acs.jafc.4c02820 | DOI Listing |
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