AI Article Synopsis
- Patients with familial adenomatous polyposis (FAP) face both medical risks and social challenges, particularly related to marriage and childbirth after undergoing colorectal surgery.
- A study of 161 Japanese patients showed that the overall marriage rate post-surgery (57.8%) was similar to that of the general Japanese population, but those unmarried before surgery had a low marriage rate (16.0%).
- Factors like younger age and genetic testing significantly increased the likelihood of getting married post-surgery, and 71% of those who married after surgery went on to have successful pregnancies.
Article Abstract
Background: Patients with familial adenomatous polyposis (FAP) experience psychological and social challenges concerning future events such as marriage and childbirth alongside the medical risks of colorectal cancer (CRC) and FAP-related disease. We retrospectively investigated the rate of marriage and childbirth postoperatively in Japanese patients with FAP.
Methods: We included 161 patients who had colorectal surgery and reported marital status from a national survey of 35 Japanese institutions. Participants were classified according to marital status: married before colectomy (80 patients), married after colectomy (13 patients), and unmarried (68 patients).
Results: The marriage rate for all 161 patients (57.8%, standardized ratio 0.95, 95% confidence interval [CI] 0.76-1.14) was comparable to that in the general Japanese population (57.1%). The marriage rate among the 81 patients who were unmarried before colectomy was low (16.0%); however, the standardized marital ratio (0.75, 95% CI 0.34-1.15) was not significantly lower than that of the general population. In multivariable logistic regression, younger age (born after 1980, odds ratio [OR] 0.12, p < 0.001) and genetic testing (OR 4.06, p = 0.001) were associated with postoperative marriage. Seventy-one percent of patients with FAP who married after colectomy became pregnant and achieved delivery.
Conclusions: The marriage rate of patients with FAP was comparable to that of the general population whereas the rate after colectomy was low among patients with FAP. However, in patients with FAP, colorectal surgery itself may not lead to negative consequences in terms of fecundity.
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| http://dx.doi.org/10.1007/s10147-024-02558-4 | DOI Listing |
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