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Correction: CADM2 Participates in Endometriosis Development by Influencing the Epithelial-mesenchymal Transition.
Reprod Sci
July 2024
Department of Reproductive Medicine, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong Province, People's Republic of China.
KnockoffTrio: A knockoff framework for the identification of putative causal variants in genome-wide association studies with trio design.
Am J Hum Genet
October 2022
Department of Biostatistics, Columbia University, New York, NY 10032, USA. Electronic address:
Family-based designs can eliminate confounding due to population substructure and can distinguish direct from indirect genetic effects, but these designs are underpowered due to limited sample sizes. Here, we propose KnockoffTrio, a statistical method to identify putative causal genetic variants for father-mother-child trio design built upon a recently developed knockoff framework in statistics. KnockoffTrio controls the false discovery rate (FDR) in the presence of arbitrary correlations among tests and is less conservative and thus more powerful than the conventional methods that control the family-wise error rate via Bonferroni correction.
View Article and Find Full Text PDFLongitudinal genetic studies of cognitive characteristics.
Vavilovskii Zhurnal Genet Selektsii
February 2020
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia M.V. Lomonosov Moscow State University, Laboratory of psychology of professions and conflicts, Moscow, Russia.
The present review describes longitudinal studies of cognitive traits and functions determining the causes of their variations and their possible correction to prevent cognitive impairment. The present study reviews the involvement of such environmental factors as nutrition, prenatal maternal stress, social isolation and others in cognitive functioning. The role of epigenetic factors in the implementation of environmental effects in cognitive characteristics is revealed.
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