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Transcriptional and Translational Regulation of Differentially Expressed Genes in Yucatan Miniswine Brain Tissues following Traumatic Brain Injury. | LitMetric

AI Article Synopsis

  • Traumatic brain injury (TBI) is a major global health issue that leads to various long-term problems, including motor, cognitive, and emotional difficulties.
  • * The complexities of TBI's effects and the lack of effective treatments stem from limited understanding of the brain's cellular and molecular responses to injury.
  • * In a pilot study involving Yucatan miniswine, researchers conducted RNA sequencing to identify genes affected by TBI and explored how electromagnetic field treatment influenced gene expression in injured brain tissues.

Article Abstract

Traumatic brain injury (TBI) is a leading cause of morbidity, disability, and mortality worldwide. Motor and cognitive deficits and emotional disturbances are long-term consequences of TBI. A lack of effective treatment for TBI-induced neural damage, functional impairments, and cognitive deficits makes it challenging in the recovery following TBI. One of the reasons may be the lack of knowledge underlying the complex pathophysiology of TBI and the regulatory factors involved in the cellular and molecular mechanisms of inflammation, neural regeneration, and injury repair. These mechanisms involve a change in the expression of various proteins encoded by genes whose expression is regulated by transcription factors (TFs) at the transcriptional level and microRNA (miRs) at the mRNA level. In this pilot study, we performed the RNA sequencing of injured tissues and non-injured tissues from the brain of Yucatan miniswine and analyzed the sequencing data for differentially expressed genes (DEGs) and the TFs and miRs regulating the expression of DEGs using in-silico analysis. We also compared the effect of the electromagnetic field (EMF) applied to the injured miniswine on the expression profile of various DEGs. The results of this pilot study revealed a few DEGs that were significantly upregulated in the injured brain tissue and the EMF stimulation showed effect on their expression profile.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138201PMC
http://dx.doi.org/10.26502/jbsb.5107080DOI Listing

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