AI Article Synopsis
- Transplantation is a radical therapy that involves removing the liver and its associated structures, then replacing them with a donor liver (allograft).
- Recent studies show liver transplantation is possible for patients with unresectable colorectal liver metastases (CRLM) and can lead to acceptable outcomes in carefully selected individuals.
- There are ethical concerns about this approach, such as the risk of disease recurrence in patients who are immunosuppressed and the limited availability of donor livers, which may affect access for those with other liver conditions.
Article Abstract
Transplantation represents the most radical locoregional therapy through removal of the liver, associated vasculature and locoregional lymph nodes, and replacing it with an allograft. Recent evidence has demonstrated that transplantation for unresectable CRLM is feasible with acceptable post-transplant outcomes in a highly selected cohort of patients. Controversy exists regarding whether transplantation is an appropriate treatment for such patients, due to concerns regarding disease recurrence in the transplanted graft in an immunosuppressed recipient along with utilising a donor liver which are in short supply. Expanding the indications for liver transplantation may also limit access for other patients with end-stage liver disease having ethical implications due to the effect of increasing the waiting list. In this review, we summarise the current evidence for liver transplantation in patients with nonresectable CRLM and highlight unresolved controversies and future directions for this type of treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11133248 | PMC |
| http://dx.doi.org/10.1007/s13193-023-01827-4 | DOI Listing |
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