The co-occurrence of plasmid-mediated multidrug resistance and hypervirulence in epidemic carbapenem-resistant has emerged as a global public health issue. In this study, an ST23 carbapenem-resistant hypervirulent (CR-HvKP) strain VH1-2 was identified from cucumber in China and harbored a novel hybrid plasmid pVH1-2-VIR. The plasmid pVH1-2-VIR carrying both virulence and multidrug-resistance (MDR) genes was likely generated through the recombination of a virulence plasmid and an IncFIIK conjugative MDR plasmid in clinical ST23 18622 isolated from a sputum sample. The plasmid pVH1-2-VIR exhibited the capacity for transfer to the clinical ST11 carbapenem-resistant (CRKP) strain via conjugation assay. Acquisition of pVH1-2-VIR plasmid directly converted a CRKP into CR-HvKP strain characterized by hypermucoviscosity, heightened virulence for larvae, and increased colonization ability in the mouse intestine. The emergence of such a hybrid plasmid may expedite the spread of CR-HvKP strains, posing a significant risk to human health.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10989919 | PMC |
| http://dx.doi.org/10.1002/mlf2.12086 | DOI Listing |
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The co-occurrence of plasmid-mediated multidrug resistance and hypervirulence in epidemic carbapenem-resistant has emerged as a global public health issue. In this study, an ST23 carbapenem-resistant hypervirulent (CR-HvKP) strain VH1-2 was identified from cucumber in China and harbored a novel hybrid plasmid pVH1-2-VIR. The plasmid pVH1-2-VIR carrying both virulence and multidrug-resistance (MDR) genes was likely generated through the recombination of a virulence plasmid and an IncFIIK conjugative MDR plasmid in clinical ST23 18622 isolated from a sputum sample.
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