Seborrheic Pemphigus: A Misunderstood Variant of Pemphigus Foliaceus.

Cureus

Dermatología, Instituto Dermatológico de Jalisco, Zapopan, MEX.

Published: April 2024

AI Article Synopsis

  • Seborrheic pemphigus (SP) is a localized and superficial skin condition often confused with seborrheic dermatitis (SD) and pemphigus erythematosus (PE), highlighting the challenges in accurate diagnosis due to similar symptoms.
  • A case study of a 38-year-old woman illustrates the importance of thorough clinical and histopathological analysis to correctly identify SP after an initial misdiagnosis of SD.
  • The study emphasizes the effectiveness of topical treatments for SP, contrasting with the systemic therapies typically needed for PE, and calls for more research to enhance management strategies and clarify terminology in dermatological practice.

Article Abstract

Seborrheic pemphigus (SP) represents a localized and superficial form of pemphigus foliaceus (PF) often mistaken for other dermatological conditions such as seborrheic dermatitis (SD) due to clinical similarities. Additionally, SP may be conceptually confused with pemphigus erythematosus (PE) due to historical terminology and overlapping clinical features. We present a case study of a 38-year-old female initially diagnosed with SD but later identified as SP through detailed clinical and histopathological analysis. We discuss the challenges in accurately diagnosing SP, emphasizing the importance of distinguishing it from PE and other acantholytic dermatoses. Furthermore, we highlight the effectiveness of topical treatment in managing SP, contrary to the systemic therapy often required for PE. Our findings underscore the necessity for further research to optimize management strategies for SP and emphasize the significance of precise terminology in clinical practice and research.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139437PMC
http://dx.doi.org/10.7759/cureus.59389DOI Listing

Publication Analysis

Top Keywords

seborrheic pemphigus
8
pemphigus foliaceus
8
pemphigus misunderstood
4
misunderstood variant
4
pemphigus
4
variant pemphigus
4
foliaceus seborrheic
4
pemphigus represents
4
represents localized
4
localized superficial
4

Similar Publications

This case discusses a 55-year-old patient who was evaluated at a dermatology outpatient clinic for a chronic, pruritic, and painful hyperkeratotic plaque located on her scalp vertex. Given the size of the plaque and its thick, yellow scales, an initial clinical diagnosis of seborrheic dermatitis was favored. However, after weeks of unsuccessful treatment with ketoconazole shampoo, topical fluocinolone 0.

View Article and Find Full Text PDF
Article Synopsis
  • The study used two-sample Mendelian randomization (MR) to investigate the links between inflammatory or autoimmune skin diseases and thyroid diseases.
  • Genetic data was analyzed from a large sample of participants with various skin conditions and thyroid disorders to assess risks.
  • Key findings indicated that atopic dermatitis (AD), systemic lupus erythematosus (SLE), and seborrheic dermatitis (SD) significantly increase the risk of hypothyroidism, while bullous pemphigoid (BP) lowers that risk; no causal effects were found for hyperthyroidism.
View Article and Find Full Text PDF
Article Synopsis
  • * Various skin lesions appeared at different times post-infection, with severe cases linked to specific rashes, and 19.47% of patients experienced recurrence or worsening of pre-existing skin conditions, most notably dermatitis.
  • * The findings contribute to the understanding of the dermatologic impacts of COVID-19, highlighting the need for awareness of cutaneous symptoms in affected patients.
View Article and Find Full Text PDF
Article Synopsis
  • * It discusses various skin conditions linked to Parkinson's, like seborrheic dermatitis and autoimmune diseases, suggesting possible shared biological mechanisms.
  • * The review also emphasizes the role of skin biopsies in diagnosing these diseases, particularly identifying biomarkers like α-synuclein, which could lead to improved diagnostic methods and a more comprehensive understanding of Lewy body disease.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!