and expression in colorectal carcinoma patients undergoing radical surgery and their correlation with lymph node metastasis.

Background: Few studies have investigated the expression of and in patients undergoing radical surgery for colorectal carcinoma (CRC) and their association with lymph node metastasis (LNM). Therefore, more relevant studies and analyses need to be conducted.

Aim: To explore and expression in patients undergoing radical surgery for CRC and their correlation with LNM.

Methods: This study selected 103 patients with CRC admitted to our hospital between April 2020 and April 2023. Sample specimens of CRC and adjacent tissues were collected to determine the positive rates and expression levels of and . The correlation of the two genes with patients' clinicopathological data ( LNM) was explored, and differences in and expression between patients with LNM and those without were analyzed. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive potential of the two genes for LNM in patients with CRC.

Results: Significantly higher positive rates and expression levels of and were observed in CRC tissue samples compared with adjacent tissues. and were strongly linked to LNM in patients undergoing radical surgery for CRC, with higher and levels found in patients with LNM than in those without. The areas under the ROC curve of and in assessing LNM in patients with CRC were 0.824 and 0.811, respectively.

Conclusion: and expression was upregulated in patients undergoing radical surgery for CRC and are significantly related to LNM in these patients. Moreover, high and expression can indicate LNM in patients with CRC undergoing radical surgery. The expression of both genes has certain diagnostic and therapeutic significance.