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Gender disparities in all-cause mortality among individuals with early-onset cardiovascular diseases. | LitMetric

Gender disparities in all-cause mortality among individuals with early-onset cardiovascular diseases.

BMC Public Health

Department of Cardiology, Tangshan Gongren Hospital, No. 27, Wenhua Road, Lubei District, Tangshan, 063000, Hebei Province, People's Republic of China.

Published: May 2024

AI Article Synopsis

  • * Data from the Kailuan Study, involving 2,829 participants, showed that men had a higher hazard ratio (HR: 1.42) for mortality, especially with factors like high hs-CRP levels and reduced kidney function increasing this risk for both genders.
  • * The findings stress the need for gender-specific strategies in healthcare to address these disparities and improve survival outcomes for those with early-onset cardiovascular disease.

Article Abstract

Background And Objective: Gender disparities in mortality among individuals with early-onset cardiovascular disease (CVD) remain uncertain. This study aimed to investigate gender differences in all-cause mortality and identify influencing factors.

Methods: Data extracted from the Kailuan Study, a prospective cohort study initiated in 2006, were analyzed. A total of 2,829 participants with early-onset CVD were included. Cox proportional hazard models were used to assess hazard ratios (HR) and 95% confidence intervals (CI) for gender disparities in all-cause mortality, adjusting for various factors.

Results: Males experienced a median follow-up duration of 7.54 years with 276 recorded deaths, and females had a median follow-up of 6.45 years with 105 recorded deaths. Gender disparities in all-cause mortality were observed, with men experiencing a higher all-cause mortality risk compared to women (HR: 1.42, 95% CI: 1.04, 1.92) in the fully adjusted model. Both in men and women with early-onset CVD, elevated hs-CRP levels and an eGFR < 60 mL/min/1.73m notably escalated the risk of all-cause mortality. Furthermore, the utilization of antiplatelet agents and successful blood glucose control might mitigate the risk of all-cause mortality. Smoking and eGFR decline modified the association between gender and all-cause death, women were more vulnerable to tobacco consumption and kidney misfunctioning than men (P-interaction = 0.019).

Conclusion: The study highlights gender disparities in all-cause mortality among individuals with early-onset CVD, with men experiencing a higher risk of mortality compared to women. Addressing these disparities is important for improving outcomes in this population. Further research is needed to develop sex-specific interventions and strategies to reduce gender-related mortality disparities in early-onset CVD.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140924PMC
http://dx.doi.org/10.1186/s12889-024-18908-wDOI Listing

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