AI Article Synopsis
- Organismal aging leads to declines in both bodily and reproductive functions, with various strategies identified to extend lifespan across different species.
- The study created the Cell Atlas of Worm Aging (CAWA) to analyze age-related molecular changes in different cell types, revealing unique aging signatures and developing aging clocks for various tissues.
- It also uncovered cell-specific changes in alternative polyadenylation (APA) during aging and how different lifespan-extending strategies uniquely impact these changes, enhancing understanding of aging mechanisms.
Article Abstract
Organismal aging involves functional declines in both somatic and reproductive tissues. Multiple strategies have been discovered to extend lifespan across species. However, how age-related molecular changes differ among various tissues and how those lifespan-extending strategies slow tissue aging in distinct manners remain unclear. Here we generated the transcriptomic Cell Atlas of Worm Aging (CAWA, http://mengwanglab.org/atlas ) of wild-type and long-lived strains. We discovered cell-specific, age-related molecular and functional signatures across all somatic and germ cell types. We developed transcriptomic aging clocks for different tissues and quantitatively determined how three different pro-longevity strategies slow tissue aging distinctively. Furthermore, through genome-wide profiling of alternative polyadenylation (APA) events in different tissues, we discovered cell-type-specific APA changes during aging and revealed how these changes are differentially affected by the pro-longevity strategies. Together, this study offers fundamental molecular insights into both somatic and reproductive aging and provides a valuable resource for in-depth understanding of the diversity of pro-longevity mechanisms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11257944 | PMC |
| http://dx.doi.org/10.1038/s43587-024-00631-1 | DOI Listing |
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