AI Article Synopsis
- A study explored circadian rhythms in the globus pallidus internus (GPi) of Parkinson's disease patients, focusing on a cohort of 93 subjects with 130 recordings taken in their home environments.
- Results revealed that 82.4% of subjects showed changes in GPi activity between day and night, with some experiencing reduced activity at night and others an increase.
- Higher frequency activity (>20 Hz) in GPi was more likely to decrease at night, especially in patients on extended-release levodopa, indicating that fluctuating GPi activity could impact future neurostimulation treatments.
Article Abstract
Circadian rhythms have been shown in the subthalamic nucleus (STN) in Parkinson's disease (PD), but only a few studies have focused on the globus pallidus internus (GPi). This retrospective study investigates GPi circadian rhythms in a large cohort of subjects with PD (130 recordings from 93 subjects) with GPi activity chronically recorded in their home environment. We found a significant change in GPi activity between daytime and nighttime in most subjects (82.4%), with a reduction in GPi activity at nighttime in 56.2% of recordings and an increase in activity in 26.2%. GPi activity in higher frequency bands ( > 20 Hz) was more likely to decrease at night and in patients taking extended-release levodopa medication. Our results suggest that circadian fluctuations in the GPi vary across individuals and that increased power at night might be due to the reemergence of pathological neural activity. These findings should be considered to ensure successful implementation of adaptive neurostimulation paradigms in the real-world.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139908 | PMC |
| http://dx.doi.org/10.1038/s41467-024-48732-0 | DOI Listing |
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