Piezos are force-gated ion channels that detect and communicate membrane tension to the cell. Recent work from Ullah, Nosyreva, and colleagues characterizes partial channel openings, known as subconductance states, and develops a new gating model of Piezo1 function.
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| http://dx.doi.org/10.1016/j.tibs.2024.05.005 | DOI Listing |
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Article Synopsis
- The study investigates the behavior of Piezo1 channels, which open in response to mechanical pressure, focusing on their transition from closed to open states.
- Researchers used advanced pressure-clamp recordings to analyze new subconductance states of Piezo1, revealing that pressure increases the open state while reducing closed states.
- By employing Markov-chain modeling, the team developed a four-state kinetic model that accurately describes the channel's function, aiding future research into Piezo1's role in different cell types.
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