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Intestinal Fatty Acid-Binding Protein as a Potential Biomarker for Gastrointestinal Complications after Complex Endovascular Aortic Surgery. | LitMetric

Intestinal Fatty Acid-Binding Protein as a Potential Biomarker for Gastrointestinal Complications after Complex Endovascular Aortic Surgery.

Ann Vasc Surg

Faculty of Medicine and Health, Department of Cardiothoracic and Vascular Surgery, Örebro University, Örebro University Hospital, Örebro, Sweden; School of Medical Sciences, Örebro University, Örebro, Sweden.

Published: September 2024

AI Article Synopsis

  • The study explored the link between intestinal fatty acid-binding protein (I-FABP) levels and acute gastrointestinal injury (AGI) grades in patients undergoing endovascular aortic aneurysm repair.
  • Higher I-FABP concentrations at 24 and 48 hours post-surgery correlated with increased AGI grades on the first three postoperative days, as well as a higher incidence of gastrointestinal complications.
  • These findings suggest that monitoring I-FABP levels and AGI grades could help improve the management of GI complications in patients after this type of surgery.

Article Abstract

Background: This study aimed to investigate the association between intestinal fatty acid-binding protein (I-FABP), acute gastrointestinal injury (AGI) grade, and gastrointestinal (GI) complications after fenestrated or branched endovascular aortic aneurysm repair.

Methods: A total of 17 patients undergoing endovascular aortic repair for thoracoabdominal, juxtarenal, suprarenal, or pararenal aneurysm between May 2017 and September 2018 were enrolled. Blood samples were collected preoperatively and during postoperative intensive care. The blood samples were analyzed for I-FABP with enzyme-linked immunosorbent assay. Gastrointestinal function was assessed according to the AGI grade every day during postoperative intensive care.

Results: Higher concentrations of I-FABP at 24 hr and 48 hr correlated to higher AGI grade on postoperative days 1, 2, and 3 (P = 0.032 and P = 0.048, P = 0.040 and P = 0.018, and P = 0.012 and P = 0.016, respectively). Patients who developed a GI complication within 90 days postoperatively had a higher overall AGI grade than those who did not develop a GI complication (P < 0.001), as well as higher concentrations of I-FABP at 48 hrs (P = 0.019). Patients developing GI dysfunction (AGI grade ≥2) had a higher frequency of complications (P = 0.009) and longer length of stay in the intensive care unit (P = 0.008).

Conclusions: In patients undergoing endovascular aortic repair for complex aneurysm increased postoperative plasma I-FABP concentrations and postoperative GI dysfunction, evaluated using the AGI grade, were associated with GI complications, indicating that these measures may be useful in the postoperative management of these patients.

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Source
http://dx.doi.org/10.1016/j.avsg.2024.03.023DOI Listing

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