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| http://dx.doi.org/10.34067/KID.0000000000000436 | DOI Listing |
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Out of the Cold: Does the Immunoproteasome Play a Role in Kidney Graft Function after Cold Storage?
Kidney360
May 2024
Department of Physiology, Augusta University, Augusta, Georgia.
Cold Storage Followed by Transplantation Induces Immunoproteasome in Rat Kidney Allografts: Inhibition of Immunoproteasome Does Not Improve Function.
Kidney360
May 2024
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Key Points: Cold storage (CS) increases the severity of graft dysfunction in a time-dependent manner, and prolonged CS decreases animal survival. CS plus transplant increases iproeasome levels/assembly in renal allografts; IFN- is a potential inducer of the iproteasome. Inhibiting iproteasome during renal CS did not confer graft protection after transplantation.
View Article and Find Full Text PDFNakajo-Nishimura Syndrome: The First African Case.
Mediterr J Rheumatol
June 2023
Rheumatology Clinic, Batna, Algeria.
Nakajo-Nishimura syndrome is a hereditary autoinflammatory disorder caused by an autosomal recessive homozygous mutation of the PSMB8 gene, which encodes the immunoproteasome subunit beta 5i. The clinical manifestations of NNS are mainly pernio-like skin rashes, nodular erythema, lipodystrophy, clubbed fingers, remittent fever, hepatosplenomegaly, and basal ganglia calcifications. Here we are reporting a case of NNS in an 11-year-old girl, who lives in eastern Algeria, born from a first-degree consanguineous marriage, she presented with erythematous patches on her face and her back, nodular erythema on her neck, swollen and painful fingers with acrocyanosis and recurrent fever that mainly occurred in cold weather.
View Article and Find Full Text PDFCANDLE Syndrome As a Paradigm of Proteasome-Related Autoinflammation.
Front Immunol
August 2017
Department of Dermatology, Hospital Infantil del Niño Jesús, Madrid, Spain.
CANDLE syndrome (hronic typical eutrophilic ermatosis with ipodystrophy and levated temperature) is a rare, genetic autoinflammatory disease due to abnormal functioning of the multicatalytic system proteasome-immunoproteasome. Several recessive mutations in different protein subunits of this system, located in one single subunit (monogenic, homozygous, or compound heterozygous) or in two different ones (digenic and compound heterozygous), cause variable defects in catalytic activity of the proteasome-immunoproteasome. The final result is a sustained production of type 1 interferons (IFNs) that can be very much increased by banal triggers such as cold, stress, or viral infections.
View Article and Find Full Text PDFCoevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates.
Immunol Rev
September 2015
Department of Microbiology and Immunology, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA.
Comparative immunology provides the long view of what is conserved across all vertebrate taxa versus what is specific to particular organisms or group of organisms. Regarding the major histocompatibility complex (MHC) and coevolution, three striking cases have been revealed in cold-blooded vertebrates: lineages of class Ia antigen-processing and -presenting genes, evolutionary conservation of NKT-class Ib recognition, and the ancient emergence of the natural cytotoxicity receptor NKp30 and its ligand B7H6. While coevolution of transporter associated with antigen processing (TAP) and class Ia has been documented in endothermic birds and two mammals, lineages of LMP7 are restricted to ectotherms.
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