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Analysis of the 2-Bag Method for the Management of Diabetic Ketoacidosis: A Retrospective before and after Study.
J Pharm Pract
February 2025
Michigan Medicine, Ann Arbor, MI, USA.
Article Synopsis
- This study compares the effectiveness and safety of a two-bag method versus a one-bag method for treating diabetic ketoacidosis (DKA) in patients, hypothesizing that the two-bag method will lower hypoglycemia rates.
- A total of 1,084 adult patients' charts were analyzed, revealing that the incidence of hypoglycemia was significantly lower in the two-bag group (15.83%) compared to the one-bag group (38%).
- The two-bag method also resulted in shorter insulin infusion times and quicker anion gap and HCO3 correction, suggesting better overall outcomes for DKA treatment.
Outcomes with one-bag desensitization protocol for biologic and chemotherapy agents in 451 procedures.
Eur Ann Allergy Clin Immunol
May 2024
Department of Allergy, Faculty of Medicine, Complejo Hospitalario Universitario de Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain.
Fluids in the treatment of diabetic ketoacidosis in children: A systematic review.
J Evid Based Med
June 2024
Department of Pediatrics, Universidad de Antioquia, Medellín, Colombia.
Aim: To determine the comparative effectiveness of fluid schemes for children with diabetic ketoacidosis (DKA).
Methods: We conducted a systematic review with an attempt to conduct network meta-analysis (NMA). We searched MEDLINE, EMBASE, CENTRAL, Epistemonikos, Virtual Health Library, and gray literature from inception to July 31, 2022.
Assessing the frequency and types of errors involved in the use of a modified intravenous N-acetylcysteine protocol for acetaminophen overdose.
CJEM
March 2024
Ontario Poison Centre, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, ON, Canada.
Background: Acetaminophen overdose is a leading cause of acute liver failure in developing countries. N-acetylcysteine (NAC) is a highly effective antidote for acetaminophen hepatotoxicity, typically initiated in the emergency department. Due to a known high rate of errors with the standard three-bag IV NAC protocol, in 2019, the Ontario Poison Center changed to a modified 3% IV NAC one-bag protocol.
View Article and Find Full Text PDFFluid therapy in diabetic ketoacidosis.
Curr Opin Clin Nutr Metab Care
March 2024
Critical Care Division, The George Institute for Global Health, Sydney, New South Wales.
Purpose Of Review: To evaluate recent evidence (2021-2023) on fluid therapy in diabetic ketoacidosis. Key evidence gaps which require generation of new evidence are discussed.
Recent Findings: Balanced crystalloid solutions, compared to the commonly recommended and used 0.
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