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A smart responsive NIR-operated chitosan-based nanoswitch to induce cascade immunogenic tumor ferroptosis via cytokine storm.
Carbohydr Polym
March 2025
College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai 201620, PR China. Electronic address:
In this work we present a near-infrared (NIR)-operated nanoswitch based on chitosan nanoparticles (EpCAM-CS-co-PNVCL@IR780/IMQ NPs) that induces cascade immunogenic tumor ferroptosis via cytokine storm. The formulation was prepared by loading a photosensitiser (IR780) and an immunotherapeutic drug (imiquimod; IMQ) into temperature- and pH-responsive chitosan-based NPs functionalized with tumor-targeting aptamers. The EpCAM aptamer can chaperone the NPs selectively into cancer cells, and allow them to enter the cell nucleus.
View Article and Find Full Text PDFFrom Marine Debris to a Valuable Medical Resource: A review on biology, chemistry, ethnopharmacology, bioactivity and application in biomedical materials of Cuttlebone.
J Ethnopharmacol
January 2025
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China. Electronic address:
Ethnopharmacological Relevance: Cuttlebone (CB), also known as SEPIAE ENDOCONCHA, is the inner shell of cuttlefish and has been employed in traditional medicine in numerous countries since antiquity. Despite its significant medicinal value, CB is often underestimated and discarded on the beach as debris in some countries, which considerably impacts the environment and economy.
The Aim Of The Review: This study aims to elucidate the value of CB, particularly in the context of its medicinal properties, to promote its rational utilization.
Antioxidant taurine inhibits chondrocyte ferroptosis through upregulation of OGT/Gpx4 signaling in osteoarthritis induced by anterior cruciate ligament transection.
J Adv Res
January 2025
Department of Rehabilitation Medicine, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, China. Electronic address:
Objective: The aim of this study was to investigate the potential molecular mechanisms by which taurine protects against cartilage degeneration.
Methods: The anterior cruciate ligament transection (ACLT) surgery was used to construct an animal model of osteoarthritis (OA). Metabolomics was used to identify characteristic metabolites in osteoarthritic chondrocytes.
Efficacy of Auricular Therapy for Motor Impairment After Stroke: A Systematic Review and Meta-Analysis.
Int J Older People Nurs
January 2025
Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
Background: A high number of stroke patients cannot recover fully from motor impairment despite early rehabilitation. Auricular therapies, usually given by acupuncture doctors or nurses, have been widely used among these post-stroke patients. Potential benefits of auricular therapies were shown in recent clinical trials.
View Article and Find Full Text PDF[Case of osteitis condensans ilii].
Zhongguo Zhen Jiu
January 2025
Department of Acupuncture and Moxibustion, Wuxi Municipal Hospital of TCM, Wuxi 214100, Jiangsu Province, China.
The paper reports one case of osteitis condensans ilii treated with acupuncture in the young and middle-aged female patient. Based on the "analogy" thinking, bilateral Chengshan (BL57) and Ximen (PC4) were selected. The short needling was delivered at Chengshan (BL57), in which, the needle tip went directly to the bone surface and the needle was lifted and thrusted to induce the tolerable sensation.
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