Large cell lymphoma through a liquid lens.

Br J Haematol

Monash Haematology, Monash Health, Clayton, Victoria, Australia.

Published: July 2024

AI Article Synopsis

  • Liquid biopsy is an innovative method that analyzes cell-free DNA to offer insights into diffuse large B-cell lymphoma (DLBCL), a type of cancer.
  • The study by Alcoceba et al. evaluates how effective the EuroClonality-NDC assay is for profiling DLBCL and its potential for practical use.
  • Achieving a major molecular response through this method has important implications for predicting patient outcomes and assessing treatment effectiveness.

Article Abstract

Liquid biopsy to provide a mutational snapshot of diffuse large B-cell lymphoma is an emerging technology of exciting potential utility. The report by Alcoceba et al. assesses the tractability of the EuroClonality-NDC assay to profile lymphoma using cell-free DNA and highlights the prognostic implication of attaining a major molecular response to therapy. Commentary on: Alcoceba et al. Liquid biopsy for molecular characterization of diffuse large B-cell lymphoma and early assessment of minimal residual disease. Br J Haematol 2024;205:109-121.

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Source
http://dx.doi.org/10.1111/bjh.19502DOI Listing

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