AI Article Synopsis
- The study addresses a key challenge in treating glioblastoma (GBM) by using a new device that offers continuous access to tumors, improving our understanding of tumor progression and treatment responses.
- Researchers tested an aligned nanofiber device in rodent models and found it to be safe, providing ample high-quality samples for genomic analyses and allowing for the study of tumor behavior over time.
- The findings suggest that this device could become a valuable tool for monitoring GBM and tailoring clinical treatments based on real-time data from the tumor environment.
Article Abstract
Background: A major hurdle to effectively treating glioblastoma (GBM) patients is the lack of longitudinal information about tumor progression, evolution, and treatment response.
Methods: In this study, we report the use of a neural tract-inspired conduit containing aligned polymeric nanofibers (i.e., an aligned nanofiber device) to enable on-demand access to GBM tumors in 2 rodent models. Depending on the experiment, a humanized U87MG xenograft and/or F98-GFP+ syngeneic rat tumor model was chosen to test the safety and functionality of the device in providing continuous sampling access to the tumor and its microenvironment.
Results: The aligned nanofiber device was safe and provided a high quantity of quality genomic materials suitable for omics analyses and yielded a sufficient number of live cells for expansion and screening. Transcriptomic and genomic analyses demonstrated continuity between material extracted from the device and that of the primary, intracortical tumor (in the model).
Conclusions: The results establish the potential of this neural tract-inspired, aligned nanofiber device as an on-demand, safe, and minimally invasive access point, thus enabling rapid, high-throughput, longitudinal assessment of tumor and its microenvironment, ultimately leading to more informed clinical treatment strategies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135361 | PMC |
| http://dx.doi.org/10.1093/noajnl/vdae064 | DOI Listing |
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Article Synopsis
- The study addresses a key challenge in treating glioblastoma (GBM) by using a new device that offers continuous access to tumors, improving our understanding of tumor progression and treatment responses.
- Researchers tested an aligned nanofiber device in rodent models and found it to be safe, providing ample high-quality samples for genomic analyses and allowing for the study of tumor behavior over time.
- The findings suggest that this device could become a valuable tool for monitoring GBM and tailoring clinical treatments based on real-time data from the tumor environment.
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