AI Article Synopsis
- This study investigates the link between the total time from symptom onset to balloon treatment (S2BT) and the risk of developing new ventricular arrhythmias (VAs) in patients who suffered a heart attack (STEMI) and underwent a procedure called PCI.
- A total of 517 patients were examined, revealing that those with a shorter S2BT (≤ 24 hours) had a lower risk of VAs and better heart function after treatment, while those with an S2BT of 24 hours to 7 days had a higher risk.
- The findings suggest that S2BT has a complex relationship with VAs, with the highest risk occurring at around 68.4 hours after symptom onset.
Article Abstract
Background: Ventricular arrhythmias (VAs) mainly occur in the early post-myocardial infarction (MI) period. However, studies examining the association between total myocardial ischemia time interval and the risk of new-onset VAs during a long-term follow-up are scarce.
Methods: This study (symptom-to-balloon time and ntricular arhthmias in patients with , VERY-STEMI study) was a multicenter, observational cohort and real-world study, which included patients with ST-segment elevation MI (STEMI) undergoing percutaneous coronary intervention (PCI). The primary endpoint was cumulative new-onset VAs during follow-up. The secondary endpoints were the major adverse cardiovascular events (MACE) and changes in left ventricular ejection fraction (ΔLVEF, %).
Results: A total of 517 patients with STEMI were included and 236 primary endpoint events occurred. After multivariable adjustments, compared to patients with S2BT of 24 h-7d, those with S2BT ≤ 24 h and S2BT > 7d had a lower risk of primary endpoint. RCS showed an inverted U-shaped relationship between S2BT and the primary endpoint, with an S2BT of 68.4 h at the inflection point. Patients with S2BT ≤ 24 h were associated with a lower risk of MACE and a 4.44 increase in LVEF, while there was no significant difference in MACE and LVEF change between the S2BT > 7d group and S2BT of 24 h-7d group.
Conclusions: S2BT of 24 h-7d in STEMI patients was associated with a higher risk of VAs during follow-up. There was an inverted U-shaped relationship between S2BT and VAs, with the highest risk at an S2BT of 68.4 h.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11133922 | PMC |
| http://dx.doi.org/10.1016/j.ijcrp.2024.200286 | DOI Listing |
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