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Global, regional, and national burden of esophageal cancer: a systematic analysis of the Global Burden of Disease Study 2021.
Biomark Res
January 2025
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Background And Objective: Esophageal cancer (EC) is the seventh most prevalent cancer globally and the sixth leading cause of cancer-related mortality. This study aimed to provide an updated stratified assessment of rates in EC incidence, mortality, and disability-adjusted life-years (DALYs) from 1990 to 2021 by sex, age, and Socio-demographic Index (SDI) at global, regional, and national levels, as well as to project the future trends of EC both globally and regionally.
Methods: Data about age-standardized rates (ASRs) of incidence (ASIR), mortality (ASDR), probability of death (ASPoD) and DALYs (ASDALYRs) of EC were obtained from the 2021 Global Burden of Disease (GBD) study.
Fragment-to-Lead Medicinal Chemistry Publications in 2023.
J Med Chem
January 2025
Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom.
This Perspective summarizes successful fragment-to-lead (F2L) studies that were published in 2023 and is the ninth installment in an annual series. A tabulated summary of the relevant articles published in 2023 is provided (17 entries from 16 articles), and a comparison of the target classes, screening methods, and overall fragment or lead property trends for 2023 examples and for the combined entries over the years 2015-2023 is discussed. In addition, we identify several trends and innovations in the 2023 literature that promise to further increase the success of fragment-based drug discovery (FBDD), particularly in the areas of NMR and virtual screening, fragment library design, and fragment linking.
View Article and Find Full Text PDFPerspective: Incidence of Clinician-Diagnosed Lyme Disease in Manitoba, Canada 2009-2018.
Vector Borne Zoonotic Dis
January 2025
Infectious Diseases and Vaccine Programs Branch, Public Health Agency of Canada, Saint-Hyacinthe, Canada.
Lyme disease (LD) surveillance yields useful information to monitor the disease trends and spatial distribution. However, due to several factors, the Manitoba Health surveillance system, as with other systems, could be subject to underreporting. To estimate the number and incidence of clinician-diagnosed LD over the study period in Manitoba, describe the epidemiology of clinician-diagnosed LD, and compare the findings with Manitoba Health LD surveillance data during the same period to estimate the extent of underreporting.
View Article and Find Full Text PDFSocial and Polygenic Risk Factors for Time to Comorbid Diagnoses in Individuals with Substance Use Disorders: A Phenome-Wide Survival Analysis.
medRxiv
December 2024
SUNY Downstate Health Sciences University, Department of Psychiatry and Behavioral Sciences.
Importance: Persons with substance use disorders (SUD) often suffer from additional comorbidities, including psychiatric conditions and physical health problems. Researchers have explored this overlap in electronic health records (EHR) using phenome wide association studies (PheWAS) to characterize how different indicators are related to all conditions in an individual's EHR. However, analyses have been largely cross-sectional in nature.
View Article and Find Full Text PDFTrends in Opioid Use Disorder in the Veterans Health Administration, 2005-2022.
JAMA Netw Open
December 2024
Department of Psychiatry, Columbia University Irving Medical Center, New York, New York.
Importance: Given the personal and social burdens of opioid use disorder (OUD), understanding time trends in OUD prevalence in large patient populations is key to planning prevention and treatment services.
Objective: To examine trends in the prevalence of OUD from 2005 to 2022 overall and by age, sex, and race and ethnicity.
Design, Setting, And Participants: This serial cross-sectional study included national Veterans Health Administration (VHA) electronic medical record data from the VHA Corporate Data Warehouse.
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