AI Article Synopsis
- - Paget disease is a type of cancer that typically affects the breast and areas rich in apocrine glands, often linked to other internal cancers; extramammary Paget disease (EMPD) in the mouth is very rare, with only eight reported cases.
- - A case study presents an 81-year-old male with oral EMPD affecting his buccal mucosa and gingiva, who did not have any known internal cancer.
- - The Paget cells in this patient showed specific positive markers (CK7, CK20, CAM5.2, androgen receptor) and negative markers (SOX10, p63), and the article reviews the immunophenotype and treatment options for oral EMPD. *
Article Abstract
Paget disease is an intraepithelial neoplastic proliferation, commonly occurring in the breast and apocrine-rich areas, often associated with an underlying internal malignancy. Extramammary Paget disease (EMPD) of the oral cavity is exceedingly rare, with only eight reported cases, four of which were associated with an underlying internal malignancy. Here, we report a case of oral EMPD involving the buccal mucosa and gingiva of an 81-year-old male with no known underlying internal malignancy. The Paget cells were positive for CK7, CK20, CAM5.2, and androgen receptor, but negative for SOX10 and p63. The immunophenotype, association with internal malignancies, and treatment approaches for oral EMPD are reviewed.
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| http://dx.doi.org/10.1111/cup.14663 | DOI Listing |
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