Raphani Semen, with both edible and medicinal values, is a typical Chinese herbal medicine with different effects before and after processing. The raw helps ascending and the cooked helps descending. This paper comprehensively summarizes the differences in chemical constituents and pharmacological effects between raw and processed Raphani Semen that are reported in recent years. Based on the principle of quality markers(Q-markers) of traditional Chinese medicines, the chemical constituent sources, chemical constituent detection techniques, and correlation between bidirectional regulatory efficacy and chemical constituents are compared between raw and processed Raphani Semen. The results suggest that sulforaphene and glucoraphanin could be used as candidate Q-markers of raw and processed Raphani Semen, respectively. This review is expected to provide a reference for further research on the processing, new drug development, and improvement of safety and effectiveness of Raphani Semen in clinical application.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20231219.201 | DOI Listing |
Phytomedicine
October 2024
State Key Laboratory of Traditional Chinese Medicine Syndrome, International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China. Electronic address:
Background: The presence of distant metastasis at the time of initial diagnosis is a prevalent issue in non-small cell lung cancer (NSCLC), affecting around 30-40 % of the patients. Acidic tumor microenvironment (TME) provides favorable conditions that increase the invasiveness and aggressiveness of NSCLC. The activity of the glycolytic enzyme lactate dehydrogenase (LDHA) increases intracellular lactate accumulation, which creates an acidic TME.
View Article and Find Full Text PDFCarbohydr Polym
October 2024
Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, Heilongjiang, China; Key Laboratory of Gut Microbiota and Pharmacogenomics of Heilongjiang Province, College of Pharmacy, Harbin Medical University, Harbin 150081, Heilongjiang, China. Electronic address:
RSA-1 is a polysaccharide obtained from Raphani semen with a relatively clear structure and anti-colon cancer activity. In this study, high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and nuclear magnetic resonance (NMR) spectroscopy were applied to characterise the complex chain structure of RSA-1. Subsequently, the inhibitory effect on colon cancer growth through apoptosis induction in colon cancer cells was explored.
View Article and Find Full Text PDFJ Asian Nat Prod Res
December 2024
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
This study examined the impact of Semen raphani on the absorption of ginsenosides from C.A. Meyer (ginseng) using a Caco-2 cell model and Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (UPLC-ESI-MS).
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
April 2024
School of Biomedical and Pharmaceutical Science, Guangdong University of Technology Guangzhou 510006, China.
Raphani Semen, with both edible and medicinal values, is a typical Chinese herbal medicine with different effects before and after processing. The raw helps ascending and the cooked helps descending. This paper comprehensively summarizes the differences in chemical constituents and pharmacological effects between raw and processed Raphani Semen that are reported in recent years.
View Article and Find Full Text PDFNat Prod Res
April 2024
Shandong Academy of Chinese Medicine, Jinan, China.
A new compound named raphanised A (), along with two known methylsulfinyl -butanyl derivatives () and seven known indole derivatives (), were isolated from the Raphani Semen. Among the indole derivatives, was identified as a new natural product, and , , , , , were isolated from the genus of for the first time. Their structures were elucidated based on the NMR and HR-EI-MS analysis.
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