Chronic kidney disease(CKD) is an insidious disease that has become a significant global public health issue due to its high incidence rate, low awareness, low diagnostic rate, poor prognosis, and high medical costs. Recent studies have shown that CKD development is associated with varying degrees of ferroptosis features. Traditional Chinese medicine(TCM) can regulate iron metabolism, lipid peroxidation, antioxidant systems to inhibit ferroptosis and delay the progression of CKD. Consequently, the intervention mechanism of ferroptosis has become one of the focuses of CKD research. TCM has thousands of years of traditional experience and wisdom. It focuses on the overall regulation of human body functions and can stimulate the body's disease resistance and recovery capabilities, which has certain advantages in treating CKD. However, there is currently a lack of comprehensive articles on the application of TCM in intervening ferroptosis to treat CKD and the pathogenesis of ferroptosis in CKD. Therefore, this article summarizes the latest research progress both domestically and internationally, briefly introduces the main mechanisms of ferroptosis, and systematically reviews the relationship between ferroptosis and CKD. The article integrates TCM theories related to ferroptosis in CKD, including "deficiency" "stasis" "phlegm turbidity" and "toxins" and summarizes the research status of active ingredients and herbal formulas in intervening ferroptosis to treat CKD. By considering ferroptosis from a new perspective, this article aims to provide new targets and directions for the application of TCM in treating CKD.
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| http://dx.doi.org/10.19540/j.cnki.cjcmm.20240111.701 | DOI Listing |
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- Renal fibrosis (RF) is a disease where excessive extracellular matrix buildup occurs, activating signaling pathways related to tissue repair and fibrosis, particularly affecting tubular epithelial cells (TECs).
- The article highlights key biological mechanisms and pathways involved in RF, including cellular senescence, ferroptosis, autophagy, epithelial-mesenchymal transition, and the TGF-β/Smad signaling pathway.
- A review of traditional Chinese medicine (TCM) finds promising results in using Chinese herbs to reduce RF and prevent chronic kidney disease (CKD), suggesting new strategies for treatment and clinical applications.
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