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Flotillin-mediated stabilization of unfolded proteins in bacterial membrane microdomains.
Nat Commun
July 2024
Department of Microbiology, National Centre for Biotechnology, Spanish National Research Council (CNB-CSIC), Madrid, 28049, Spain.
The function of many bacterial processes depends on the formation of functional membrane microdomains (FMMs), which resemble the lipid rafts of eukaryotic cells. However, the mechanism and the biological function of these membrane microdomains remain unclear. Here, we show that FMMs in the pathogen methicillin-resistant Staphylococcus aureus (MRSA) are dedicated to confining and stabilizing proteins unfolded due to cellular stress.
View Article and Find Full Text PDFCorrection: Flotillins affect LPS-induced TLR4 signaling by modulating the trafficking and abundance of CD14.
Cell Mol Life Sci
May 2024
Laboratory of Molecular Membrane Biology, Nencki Institute of Experimental Biology PAS, 3 Pasteur St, Warsaw, 02-093, Poland.
Author Correction: Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Sci Rep
August 2023
Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Erratum: Elevated expression of flotillin-1 is associated with lymph node metastasis and poor prognosis in early-stage cervical cancer.
Am J Cancer Res
November 2021
State Key Laboratory of Oncology in South China, Department of Experimental Research, Cancer Center, Sun Yat-sen University 651 Dongfeng Road East, Guangzhou 510060, Guangdong, China.
[This corrects the article on p. 38 in vol. 6, PMID: 27073721.
View Article and Find Full Text PDFCirculating small extracellular vesicles increase after an acute bout of moderate-intensity exercise in pregnant compared to non-pregnant women.
Sci Rep
June 2021
Faculty of Health Sciences, School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.
The physiological and molecular mechanisms linking prenatal physical activity and improvements in maternal-fetal health are unknown. It is hypothesized that small extracellular vesicles (EVs, ~ 10-120 nm) are involved in tissue cross-talk during exercise. We aimed to characterize the circulating small EV profile of pregnant versus non-pregnant women after an acute bout of moderate-intensity exercise.
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