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Validation of biomarkers and clinical scores for the detection of uterine leiomyosarcoma: a case-control study with an update of pLMS.
BMC Cancer
January 2025
Department of Obstetrics and Gynecology, University Medicine Greifswald, Sauerbruchstr., Greifswald, 17475, Germany.
Background: The diagnosis of rare uterine leiomyosarcoma (uLMS) remains a challenge given the high incidence rates of benign uterine tumors such as leiomyoma (LM). In the last decade, several clinical scores and blood serum markers have been proposed. The aim of this study is to validate and update the pLMS clinical scoring system, evaluating the accuracy of the scoring system by Zhang et al.
View Article and Find Full Text PDFOptical assessment of scars after endoscopic mucosal resection of large colorectal polyps in a multicenter, community hospital setting: is routine biopsy still necessary?
Endoscopy
December 2024
Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, Netherlands.
Background And Study Aims: Piecemeal EMR of large (≥20mm) non-pedunculated colorectal polyps (LNPCPs) is succeeded by a 6-month surveillance endoscopy to evaluate the post-EMR scar for recurrence. Data from expert centers suggest that routine tattoo placement and scar biopsies can be omitted, but data from community hospitals are lacking.
Patients And Methods: In a post-hoc analysis of the STAR-LNPCP study (NTR7477), containing prospective data on 6-month post-pEMR scar assessments in 30 Dutch community hospitals (October 2019 to May 2022), the agreement between optical assessment and histological confirmation by routine biopsies was evaluated.
Diversity, equity, and inclusion in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy Position Statement.
Endoscopy
November 2024
Institute of Gastroenterology and Hepatology, Emek Medical Center, Afula, Israel.
1: The European Society of Gastrointestinal Endoscopy (ESGE) adheres to the overarching principles of equality of opportunity, fair treatment, nondiscrimination, and diversity of health care professionals. 2: ESGE strongly supports the creation of collaborations within and between national and international endoscopy societies to disseminate the principles of diversity, equality, and inclusion (DEI) in the field of gastrointestinal (GI) endoscopy. 3: ESGE aims to reflect the diversity of its membership in all its scientific and educational activities.
View Article and Find Full Text PDFFertility-sparing treatment and follow-up in patients with cervical cancer, ovarian cancer, and borderline ovarian tumours: guidelines from ESGO, ESHRE, and ESGE.
Lancet Oncol
November 2024
Université Paris Saclay, Paris, France; Department of Reproductive Medicine and Fertility Preservation, Hopital Antoine Béclère, Clamart, France; Department of Reproductive Medicine and Fertility Preservation, Hopital Jean Verdier, Bondy, France.
Article Synopsis
- - The European Society of Gynaecological Oncology, alongside other societies, created evidence-based guidelines for fertility-sparing strategies in patients with cervical and ovarian cancers, as well as borderline ovarian tumors.
- - These guidelines were developed through a thorough literature review and involved a diverse group of 25 experts in multiple medical fields, ensuring a comprehensive approach.
- - Prior to release, the guidelines were vetted by 121 independent cancer care professionals and patient representatives, addressing key aspects of initial management, fertility optimization, and future pregnancy desires.
The optimal endometrial thickness threshold for prediction of endometrial cancer in postmenopausal women without bleeding remains uncertain-Systematic review and meta-analysis.
J Gynecol Obstet Hum Reprod
December 2024
Consultant Gynecologist in Sandwell and West Birmingham Hospitals NHS Trust (SWBH) and Visiting Senior Lecturer in University of Aston, Birmingham, UK. Electronic address:
The incidental finding of endometrial thickness (ET) >4 mm in the absence of postmenopausal bleeding (PMB) is a common cause of referring women to secondary care. However, there is lack of consensus amongst gynecologists as regards the management. It is estimated that up to 15 % of endometrial cancers occur in women without PMB.
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