AI Article Synopsis
- This research introduces a silver-catalyzed multi-auto-tandem reaction featuring enamines, alkynals, and nucleophiles to produce valuable compounds.
- The process utilizes a reactive intermediate called azafulvenium, leading to diverse outcomes that can be adjusted based on catalytic conditions.
- The method allows for the efficient creation of various pyrrole products with targeted functionalization and structural complexity.
Article Abstract
Here, we present a versatile, silver-catalyzed multi-auto-tandem reaction involving enamines, alkynals, and nucleophiles, utilizing the highly reactive intermediate azafulvenium. This method allows for flexible and switchable regiodivergent reactions through either intermolecular or intramolecular nucleophilic attacks, which can be controlled by adjusting the catalytic conditions. A range of site-specific functionalized or polycyclic fused pyrrole products were efficiently produced with a high level of chemocontrol.
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| http://dx.doi.org/10.1021/acs.orglett.4c01437 | DOI Listing |
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