Our previous work identified a series of 12 xanthoquinodin analogues and 2 emodin-dianthrones with broad-spectrum activities against , , , and . Analyses conducted in this study revealed that the most active analogue, xanthoquinodin A1, also inhibits tachyzoites and the liver stage of , with no cross-resistance to the known antimalarial targets PfACS, PfCARL, PfPI4K, or DHODH. In , inhibition occurs prior to multinucleation and induces parasite death following 12 h of compound exposure. This moderately fast activity has impeded resistance line generation, with xanthoquinodin A1 demonstrating an irresistible phenotype in both and .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533362 | PMC |
| http://dx.doi.org/10.1021/acsinfecdis.4c00232 | DOI Listing |
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