[This corrects the article DOI: 10.1371/journal.pone.0261696.].
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0304731 | PLOS |
It was studied the effect of doxorubicin on the HIF system and the pro-antioxidant balance of neonatal cardiomyocytes as well as the possibility of the oxidative stress correcting using curcumin. It has been revealed that the expression of mRNA HIF-1α using doxorubicin at a dose of 0.5 μM was 2.
View Article and Find Full Text PDFJ Biol Chem
August 2008
Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA.
High lactate generation and low glucose oxidation, despite normal oxygen conditions, are commonly seen in cancer cells and tumors. Historically known as the Warburg effect, this altered metabolic phenotype has long been correlated with malignant progression and poor clinical outcome. However, the mechanistic relationship between altered glucose metabolism and malignancy remains poorly understood.
View Article and Find Full Text PDFJ Biol Chem
January 2007
Department of Dermatology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA.
Src family tyrosine kinases (SFKs) are important regulators of epithelial cell growth and differentiation. Characterization of cellular mechanisms that regulate SFK activity will provide insights into the pathogenesis of diseases associated with increased SFK activity. Keratin 14-Fyn (K14) transgenic mice were derived to characterize the effect of Fyn on epidermal growth and differentiation in vivo.
View Article and Find Full Text PDFEndocrinology
December 2003
Department of Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.
We determined basal and insulin-stimulated responses on signaling intermediates in soleus skeletal muscle from male Wistar and diabetic Goto-Kakizaki (GK) rats. Rats were infused with glucose (5 or 20 mm) for 3 h, followed by a continuous infusion of saline or insulin (3 U/kg.h) for 20 min.
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