AI Article Synopsis
- The study investigates the relationship between cardiovascular health (CVH), lifestyle factors, and mild cognitive impairment (MCI) specifically in UK veterans, an area with limited research.
- Using data from the PROTECT study involving 9,378 participants, the research found that veterans with obesity, high cholesterol, or diabetes had varying risks of developing MCI compared to non-veterans.
- The findings suggest that while some lifestyle factors may reduce MCI risk in veterans, further research is needed to explore these associations and develop targeted intervention strategies.
Article Abstract
Background: The link between poor cardiovascular health (CVH), lifestyle and mild cognitive impairment (MCI) has been well established in the general population. However, there is limited research exploring these associations in ageing UK veterans.
Aims: This study explored the risk of MCI and its association with nine CVH and lifestyle risk factors (including diabetes, heart disease, high cholesterol, high blood pressure, obesity, stroke, physical inactivity, the frequency of alcohol consumption and smoking) in UK veterans and non-veterans.
Methods: This prospective cohort study comprised data from the PROTECT study between 2014 and 2022. Participants comprised of UK military veterans and non-veterans aged ≥50 years at baseline. Veteran status was defined using the Military Service History Questionnaire. CVH and lifestyle risk factors were defined using a combination of self-report measures, medication history or physical measurements. MCI was defined as the presence of subjective and objective cognitive impairment.
Results: Based on a sample of 9378 veterans (n = 488) and non-veterans (n = 8890), the findings showed the risk of MCI significantly reduced in veterans with obesity, those who frequently consumed alcohol and were physically inactive compared to non-veterans. The risk of MCI significantly increased in veterans with diabetes (hazards ratio [HR] = 2.22, 95% confidence interval [CI] 1.04-4.75, P ≤ 0.05) or high cholesterol (HR = 3.11, 95% CI 1.64-5.87, P ≤ 0.05) compared to veterans without.
Conclusions: This study identified CVH and lifestyle factors of MCI in UK veterans and non-veterans. Further work is needed to understand these associations and the underpinning mechanisms which could determine intervention strategies to reduce the risk of MCI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11165370 | PMC |
| http://dx.doi.org/10.1093/occmed/kqae027 | DOI Listing |
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