AI Article Synopsis
- * OSA can lead to both functional and structural issues in the coronary microcirculation, which disrupts the relationship between MBF and the heart's workload.
- * Early studies indicate that CPAP therapy may enhance MBF and myocardial flow reserve (MFR) in patients with moderate to severe OSA, but more research is needed to fully understand its clinical benefits.
Article Abstract
Purpose Of Review: Recent studies have demonstrated an association between obstructive sleep apnea (OSA) and abnormal myocardial blood flow (MBF), myocardial flow reserve (MFR), and coronary microvascular dysfunction (CMD). Here, we review the evidence and describe the potential underlying mechanisms linking OSA to abnormal MBF. Examining relevant studies, we assess the impact of OSA-specific therapy, such as continuous positive airway pressure (CPAP), on MBF.
Recent Findings: Recent studies suggest an association between moderate to severe OSA and abnormal MBF/MFR. OSA promotes functional and structural abnormalities of the coronary microcirculation. OSA also promotes the uncoupling of MBF to cardiac work. In a handful of studies with small sample sizes, CPAP therapy improved MBF/MFR. Moderate to severe OSA is associated with abnormal MFR, suggesting an association with CMD. Evidence suggests that CPAP therapy improves MBF. Future studies must determine the clinical impact of improved MBF with CPAP.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11886-024-02072-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sleep disorders in individuals with dentofacial deformities: a preliminary study on the relationship with sex and serotonin levels.
Oral Maxillofac Surg
January 2025
Programa de Pós-graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Purpose: It has been suggested that dentofacial deformities (DFD) can impair sleep quality. This pilot study aimed at evaluating sleep disorders in individuals with DFD before orthognathic surgery, correlating the clinical findings with salivary biomarker levels.
Methods: This cross-sectional study enrolled ten males and ten females with DFD diagnoses under orthodontic treatment preceding orthognathic surgery.
Smoking History and Nicotine Dependence Alter Sleep Features in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome.
Healthcare (Basel)
December 2024
Respiratory Failure Clinic and Sleep Laboratory, General Hospital of Thessaloniki "G. Papanikolaou", Aristotle's University of Thessaloniki, 541 24 Thessaloniki, Greece.
There are many aspects in the relationship between smoking and sleep that have not been investigated thoroughly yet, especially in regards to obstructive sleep apnea-hypopnea syndrome (OSAHS). In this cross-sectional study, 2359 participants, who have visited the sleep clinic of our hospital during a 13-year period and were former or current smokers, were included. Their smoking history, measured in packyears of smoking, and their nicotine dependence, measured with the Fagerström scale, were correlated with various epidemiological and sleep-related variables.
View Article and Find Full Text PDFGut microbiota has important roles in the obstructive sleep apnea-induced inflammation and consequent neurocognitive impairment.
Front Microbiol
December 2024
Department of Otolaryngology, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Obstructive sleep apnea (OSA) is a state of sleep disorder, characterized by repetitive episodes of apnea and chronic intermittent hypoxia. OSA has an extremely high prevalence worldwide and represents a serious challenge to public health, yet its severity is frequently underestimated. It is now well established that neurocognitive dysfunction, manifested as deficits in attention, memory, and executive functions, is a common complication observed in patients with OSA, whereas the specific pathogenesis remains poorly understood, despite the likelihood of involvement of inflammation.
View Article and Find Full Text PDFImpact of Chronic Intermittent Hypoxia on Cognitive Function and Hippocampal Neurons in Mice: A Study of Inflammatory and Oxidative Stress Pathways.
Nat Sci Sleep
December 2024
Clinical Department of National Clinical Research Center for Respiratory Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, People's Republic of China.
Purpose: Chronic intermittent hypoxia (CIH) is considered one of the main pathophysiological mechanisms of obstructive sleep apnea (OSA). CIH can further lead to cognitive dysfunction by inducing processes such as neuroinflammation and oxidative stress. The hippocampus is primarily associated with cognitive functions such as learning and memory.
View Article and Find Full Text PDFTreatment Approaches to Myasthenia Gravis and Obstructive Sleep Apnea: Case Report.
Sleep Sci
December 2024
Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil.
Article Synopsis
- Myasthenia gravis (MG) is an autoimmune disease that causes muscle weakness due to the destruction of acetylcholine receptors at the neuromuscular junction.
- Treatment for patients with both MG and obstructive sleep apnea (OSA) often includes positive pressure airway therapy, but adherence to this treatment can be challenging, leading to worse health outcomes.
- This report focuses on a case study of a 50-year-old man with MG and OSA, examining how he responded to various treatment methods.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!