AI Article Synopsis
- Pachyonychia congenita is a genetic skin disorder that is autosomal dominant, leading to severe foot pain, thickened skin on palms and soles, and nail problems.
- The chronic pain from this condition can greatly reduce a person's quality of life, and current treatment options mainly involve lifestyle changes and some mechanical methods, with only a few patients finding relief from oral medications like retinoids.
- This review explores the causes of pain associated with pachyonychia congenita and discusses existing and potential future treatments.
Article Abstract
Pachyonychia congenita (PC) is an autosomal dominant genodermatosis characterized by a triad of chronic severe plantar pain, focal palmoplantar keratoderma and hypertrophic nail dystrophy. Plantar pain can be debilitating and have a profound impact on quality of life. Current therapeutic options for pain in PC are limited to lifestyle adjustment and mechanical techniques, with a small subgroup of patients benefiting from oral retinoids. This review investigates the pathogenesis of pain in PC and provides a summary of the current and future therapeutic options.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ced/llae199 | DOI Listing |
Publication Analysis
Top Keywords
pachyonychia congenita
8
pathogenesis pain
8
plantar pain
8
therapeutic options
8
pain
5
congenita pathogenesis
4
pain approaches
4
approaches treatment
4
treatment pachyonychia
4
congenita autosomal
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!