AI Article Synopsis
- * The structures of these new compounds were determined using advanced techniques like spectroscopy and mass spectrometry, with uvarialeptones A and B being notable dimers featuring a cyclobutane ring.
- * Uvarialeptone A's structure was specifically confirmed through X-ray diffraction analysis, and it demonstrated significant biological activity by inhibiting nitric oxide production at an IC value of 6.7 ± 0.1 μM.
Article Abstract
The first phytochemical investigation of the twig extract of resulted in the isolation and identification of three new tetrahydroxanthene-1,3(2)-diones, uvarialeptones A-C, two new oxidized hexadiene derivatives, uvarialeptols A and B, together with ten known compounds. Their structures were elucidated by spectroscopic techniques and mass spectrometry. Uvarialeptones A and B were unprecedented tetrahydroxanthene-1,3(2)-dione dimers which exhibited a cyclobutane ring via [2 + 2] cycloaddition from uvarialeptone C and 9a--methyloxymitrone, respectively. The structure of uvarialeptone A was confirmed by X-ray diffraction analysis using Mo Kα radiation. Compound inhibited NO production at an IC value of 6.7 ± 0.1 μM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217936 | PMC |
| http://dx.doi.org/10.1021/acs.jnatprod.4c00248 | DOI Listing |
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