AI Article Synopsis
- Left ventricular hypertrabeculation/noncompaction (LVHT) is a heart condition often linked to neuromuscular disorders, but its connection to coronary artery disease (CAD) is not well understood.
- A study of 154 patients revealed that those with CAD were older and had more health issues like angina, diabetes, and hypertension; however, the overall rates of death or heart transplantation were similar between patients with and without CAD.
- The findings suggest that while patients with more severe CAD (3-vessel disease) may have worse outcomes, CAD does not significantly increase the overall risk of death or needing a heart transplant in those with LVHT.
Article Abstract
Background: Left ventricular hypertrabeculation/noncompaction (LVHT) is a cardiac abnormality of unknown pathogenesis, frequently associated with neuromuscular disorders. The relevance of coronary artery disease (CAD) in LVHT is largely unknown. This study aimed to assess the role of CAD as a prognostic marker in LVHT.
Methods: Data from patients with LVHT were collected from an echocardiographic laboratory. The hospital information system was retrospectively screened for coronary angiography. The association of CAD with clinical, echocardiographic, and neurologic baseline parameters was assessed. End points were all-cause death and heart transplantation.
Results: A total of 154 patients (mean [SD] age, 57 [13.7] years; 31% female) who had undergone coronary angiography between 1995 and 2020 were included in the study. Coronary angiography disclosed CAD in 53 of 154 patients. Patients with CAD were older (mean [SD] age of, 64.2 [12.9] years vs 52.7 [12.4] years; P < .001); more frequently had angina pectoris (P = .05), diabetes (P = .002), and hypertension (P = .03); and more frequently had 3 or more electrocardiographic abnormalities (P = .04) than patients without CAD. During a median (IQR) follow-up period of 6.48 (2.44-11.20) years, 39% of patients reached an end point (death, n = 56; heart transplantation, n = 4). Mortality was 4.5% per year, and the rate of death or heart transplantation did not differ between patients with and without CAD (P = .26). Patients with 3-vessel disease had a worse prognosis than patients with 1- or 2-vessel disease (P = .046).
Conclusion: In patients with LVHT, CAD does not appear to be associated with an increased rate of death or heart transplantation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11134275 | PMC |
| http://dx.doi.org/10.14503/THIJ-23-8287 | DOI Listing |
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