Biomimetic total syntheses of renifolin F and antiarone K.

The first biomimetic and concise racemic total syntheses of renifolin F and antiarone K, accomplished in 8 and 7 linear steps, respectively, are presented in this article. Our synthetic approach commences with substituted aldehydes to produce prenylated aldol products followed by ene-type intramolecular cyclization affording a five-member core ring. This key step mediated by InCl·4HO is a novel procedure first utilized in prenylated systems which directly culminates mainly into tertiary alcohols.