Tractable and commercially available esters (and amides) of β-hydroxypropionic acid serve as malonic semialdehyde proelectrophiles in enantioselective ruthenium-catalyzed hydrogen autotransfer crotylations mediated by butadiene. Through iterative asymmetric butadiene-mediated crotylations of ethyl 3-hydroxypropanoate, total syntheses of the polyketide natural products octalactin A and B were achieved in fewer steps than previously possible.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444018 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.4c01644 | DOI Listing |
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