Background: Previous studies demonstrate an association between metabolic factors and -related gastric cancer. However, the association of gastric atrophy or intestinal metaplasia (IM) with these factors remains unknown.
Methods: Data on 1603 -positive patients who underwent esophagogastroduodenoscopy between 2001 and 2021 were evaluated. The outcome measures were endoscopic atrophy, IM grade, and the incidence of endoscopically diagnosed and pathologically confirmed gastric neoplasms. Clinical factors associated with these findings were also determined.
Results: Advanced age; successful eradication; and comorbidities including diabetes mellitus (DM), hypertension, dyslipidemia, and fib4 index were significantly associated with endoscopic gastric atrophy grade. Male sex; advanced age; and comorbidities including DM, hypertension, dyslipidemia, hyperuricemia, fatty liver, aortic calcification, and fib4 index were also significantly associated with endoscopic IM grade, whereas advanced age, successful eradication, DM, fatty liver, and fib4 index were significantly associated with the incidence of gastric neoplasms.
Conclusion: Several metabolic disorders, including DM, hypertension, dyslipidemia, hyperuricemia, and fatty liver disease, are risk factors for advanced-grade gastric atrophy, intestinal metaplasia, and gastric neoplasms. Risk stratification according to these factors, particularly those with metabolic disorders, would affect EGD surveillance for -positive patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130883 | PMC |
| http://dx.doi.org/10.3390/clinpract14030062 | DOI Listing |
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