AI Article Synopsis
- Platelet count, mean platelet volume (MPV), and platelet distribution width (PDW) are valuable and cost-effective indicators for diagnosing and managing thrombocytopenia, particularly in pregnant women where anemia is also common.
- The study, conducted in New Delhi with 150 pregnant women over 28 weeks gestation, categorized participants into mild, moderate, and severe thrombocytopenia groups, revealing higher complications like anemia and the need for transfusions in the severe group.
- The findings indicate that thrombocytopenia is significantly impacted by maternal health factors and that platelet indices such as PDW and MPV are crucial in assessing the condition and predicting potential risks for both mother and fetus.
Article Abstract
Background: Platelet count and its associated indices like mean platelet volume (MPV) and platelet distribution width (PDW) are cost-effective biomarkers that are easily accessible and have a potent role in the diagnosis and management of thrombocytopenia. Since anaemia and thrombocytopenia often go together in pregnancy, it is advisable to utilise these indices for feto-maternal benefit.
Material And Methods: The study was conducted in the Department of Obstetrics and Gynaecology at a tertiary care centre in New Delhi from July 2022 to December 2023 wherein pregnant women of age 18-40 years, period of gestation >28 weeks with thrombocytopenia or abnormal platelet indices were enrolled. Women with pancytopenia, bone marrow suppression or past or current SARS-CoV-2 positive status were excluded.
Results: A total of 150 women were enrolled in the study. The mean age of study population was 25.33 ± 2.90 (range 19-34) years. Subjects were divided into three groups - Group A (mild thrombocytopenia) 24.6%, Group B (moderate thrombocytopenia) 64.6% and Group C (severe thrombocytopenia) 10.6% based on thrombocytopenia severity. Analysing the risk factors, Group C was found to have a significantly higher number of patients with anaemia (p=<0.001), fever (p=0.031), abnormal liquor volumes (p=0.004) and need for blood and platelet transfusion (p=0.077). On correlation of thrombocytopenia with abnormal platelet indices, it was observed that manual platelet count (MPC) and MPV were indirectly correlated (p=0.027). PDW was found to be directly associated with severe thrombocytopenia and indirectly associated with moderate thrombocytopenia. Conclusion: Thrombocytopenia in pregnancy is directly correlated to factors like maternal fever and anaemia, fetal growth restriction, abnormal liquor, blood products and platelet transfusions. It was also concluded that platelet indices like PDW and MPV play an important role in predicting the feto-maternal outcome and hence timely interventions can be done to improve the same.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129801 | PMC |
| http://dx.doi.org/10.7759/cureus.59156 | DOI Listing |
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