AI Article Synopsis

  • - Cardiovascular diseases (CVD) are the top global cause of death, and despite improvements in knowledge, prevention and management still face significant challenges.
  • - Vascular smooth muscle cells (VSMCs) are essential for healthy blood vessels and can change their function in response to factors like low oxygen and inflammation, which contributes to disease progression.
  • - The article discusses how understanding the mechanisms behind VSMC changes can help identify new therapeutic targets for treating cardiovascular diseases.

Article Abstract

Cardiovascular diseases (CVD) are the leading cause of death worldwide, despite advances in understanding cardiovascular health. Significant barriers still exist in effectively preventing and managing these diseases. Vascular smooth muscle cells (VSMCs) are crucial for maintaining vascular integrity and can switch between contractile and synthetic functions in response to stimuli such as hypoxia and inflammation. These transformations play a pivotal role in the progression of cardiovascular diseases, facilitating vascular modifications and disease advancement. This article synthesizes the current understanding of the mechanisms and signaling pathways regulating VSMC phenotypic transitions, highlighting their potential as therapeutic targets in cardiovascular disease interventions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11128571PMC
http://dx.doi.org/10.3389/fcvm.2024.1400780DOI Listing

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